Reference · Hormonal & Metabolic System

The Hormonal & Metabolic Cascade

An interactive map of the major hormonal axes, peripheral conversions, gut, erythroid, and RAAS / electrolyte signaling, and tissue-level effects — with pharmaceutical interventions traced through the network. Combine multiple drugs to see interactions, hover indicators to see which drugs contribute, or click any node to discover what raises or lowers it.

01 The Network

Effect type · color

↑ Primary mechanism

↓ Beneficial

↓ Adverse

↑ Incidental

↕ Mixed (drugs conflict)

Effect magnitude · size

↑ Mild · minor effect

↑ Moderate · clinically meaningful

↑ Strong · dominant effect (with halo)

Connections

Stimulates

Inhibits / feedback

Magnitudes assume standard adult dosing · hover indicators to see which drugs contribute · click any node for reverse lookup

Pharmacological influences — click any chip to toggle that drug

Raised by ↑

Lowered by ↓

02 Simulated Lab Pattern

Select drugs to see how a standard endocrine panel would shift · markers sit at mid-range when nothing is selected · hover any row for contributors

Reproductive / gonadal

Pituitary & other axes

Metabolic

Renal & electrolytes

Lipids

Hematologic

03 Pharmacological Interventions

Click any drug to add it · click again to remove · combine multiple to see interactions

Saved presets

Protocol library

A starting hormonal state. Select one or more to set baselines (autoimmune clusters, comorbid conditions), then layer drugs below to model treatment.

Awaiting selection

Select a drug to trace its cascade

Each drug highlights nodes by effect type and magnitude. Color encodes intent (primary mechanism, benefit, adverse, incidental, or mixed for conflicts). Size encodes magnitude — mild (small), moderate (standard), or strong (large with halo). Hover any indicator to see which drugs contribute.