:root {
  --bg-deep: #0F1212;
  --bg-elev-1: #161A1A;
  --bg-elev-2: #1D2222;
  --bg-elev-3: #252A2A;
  --line: #2D3333;
  --line-strong: #3A4141;
  --ink: #E8E2D5;
  --ink-dim: #A39B89;
  --ink-faint: #6B665B;
  --accent: #C9A04C;
  --accent-soft: #8A6F35;
  --accent-deep: #6B5527;

  --primary: #C9A04C;
  --primary-deep: #6B5527;
  --benefit: #4FB892;
  --benefit-deep: #1D7556;
  --adverse: #E07550;
  --adverse-deep: #A04220;
  --incidental: #6B7785;
  --incidental-deep: #3F4853;
  --mixed: #B89DC6;
  --mixed-deep: #7A6A85;

  --hpg: #8B7AB8;
  --hpa: #C66D5A;
  --hpt: #6B92B5;
  --prl: #C77A8C;
  --gh: #5BA38A;
  --metabolic: #6B95A8;
  --adrenergic: #D89460;
  --lipid: #9A8E5E;
  --peripheral: #B89968;
  --tissue: #A89A78;
  --gut: #7FA665;
  --heme: #A85A6A;
  --raas: #5F9EA0;
}

* { box-sizing: border-box; margin: 0; padding: 0; }

/* === Sticky context bar === */
.sticky-bar {
  position: fixed;
  top: 0; left: 0; right: 0;
  background: rgba(15, 18, 18, 0.92);
  backdrop-filter: blur(8px);
  -webkit-backdrop-filter: blur(8px);
  border-bottom: 1px solid var(--line);
  z-index: 50;
  transform: translateY(-100%);
  transition: transform 0.2s ease;
}
.sticky-bar.show { transform: translateY(0); }
.sticky-bar-inner {
  max-width: 1200px;
  margin: 0 auto;
  padding: 8px 24px;
  display: flex;
  align-items: center;
  gap: 16px;
  min-height: 44px;
}
.sticky-bar-nav {
  display: flex;
  gap: 2px;
  flex-shrink: 0;
}
.sticky-bar-nav a {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.08em;
  color: var(--ink-dim);
  text-decoration: none;
  padding: 5px 10px;
  border-radius: 3px;
  border: 1px solid transparent;
  transition: color 0.15s, border-color 0.15s, background 0.15s;
}
.sticky-bar-nav a:hover {
  color: var(--accent);
  border-color: var(--line-strong);
  background: var(--bg-elev-2);
}
.sticky-bar-nav a.disabled {
  opacity: 0.35;
  pointer-events: none;
}
.sticky-bar-chips {
  display: flex;
  gap: 4px;
  flex: 1;
  flex-wrap: nowrap;
  overflow-x: auto;
  scrollbar-width: none;
  -ms-overflow-style: none;
  min-width: 0;
}
.sticky-bar-chips::-webkit-scrollbar { display: none; }
.sticky-bar-chip {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  padding: 4px 9px;
  background: var(--bg-elev-2);
  border: 1px solid var(--line);
  border-radius: 3px;
  color: var(--ink);
  cursor: pointer;
  white-space: nowrap;
  transition: border-color 0.12s, color 0.12s;
}
.sticky-bar-chip:hover {
  border-color: var(--adverse);
  color: var(--adverse);
}
.sticky-bar-chip.is-phenotype {
  border-style: dashed;
  border-color: var(--peripheral);
  color: var(--peripheral);
}
.sticky-bar-chip.is-phenotype:hover {
  border-color: var(--adverse);
  color: var(--adverse);
}
.sticky-bar-chip .x {
  opacity: 0.45;
  font-size: 12px;
  line-height: 1;
}
.sticky-bar-chip:hover .x { opacity: 1; }
.sticky-bar-empty {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--ink-faint);
  font-style: italic;
  padding: 4px 0;
}
.sticky-bar-clear {
  background: transparent;
  border: 1px solid var(--line-strong);
  color: var(--ink-dim);
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.08em;
  padding: 5px 10px;
  border-radius: 3px;
  cursor: pointer;
  transition: all 0.15s;
  flex-shrink: 0;
  display: none;
}
.sticky-bar-clear:hover { border-color: var(--adverse); color: var(--adverse); }
.sticky-bar.has-active .sticky-bar-clear { display: inline-block; }

/* Live effect-count summary. Hidden when nothing is active so the bar
   collapses to just nav + clear when idle. */
.sticky-bar-summary {
  display: none;
  align-items: center;
  gap: 8px;
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  white-space: nowrap;
  flex-shrink: 0;
  color: var(--ink-dim);
  padding-left: 6px;
  border-left: 1px solid var(--line);
}
.sticky-bar.has-active .sticky-bar-summary { display: inline-flex; }
.sticky-bar-summary .arrow {
  display: inline-flex;
  align-items: baseline;
  gap: 3px;
  font-weight: 600;
}
.sticky-bar-summary .arrow.up { color: var(--benefit); }
.sticky-bar-summary .arrow.down { color: var(--adverse); }
.sticky-bar-summary .arrow.mixed { color: var(--mixed); }
.sticky-bar-summary .arrow .glyph { font-size: 11px; }
.sticky-bar-summary .ix-badge {
  background: var(--mixed);
  color: var(--bg-deep);
  padding: 2px 7px;
  border-radius: 2px;
  font-weight: 600;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  font-size: 9px;
}
.sticky-bar-summary .ix-badge.sev-caution { background: var(--adverse); }

/* Keep section anchors clear of the fixed sticky bar when jumping. */
#section-network,
#section-labs,
#section-drugs,
#info-panel { scroll-margin-top: 60px; }

body {
  background: var(--bg-deep);
  color: var(--ink);
  font-family: 'Manrope', -apple-system, sans-serif;
  font-weight: 400;
  line-height: 1.55;
  min-height: 100vh;
  padding: 48px 24px 64px;
  background-image:
    radial-gradient(ellipse at top, rgba(201, 160, 76, 0.04), transparent 60%),
    radial-gradient(ellipse at bottom right, rgba(139, 122, 184, 0.03), transparent 50%);
}

.container { max-width: 1200px; margin: 0 auto; }

header { border-bottom: 1px solid var(--line); padding-bottom: 32px; margin-bottom: 40px; }

.eyebrow {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  text-transform: uppercase;
  letter-spacing: 0.2em;
  color: var(--accent);
  margin-bottom: 16px;
  display: flex;
  align-items: center;
  gap: 12px;
}
.eyebrow::before, .eyebrow::after { content: ''; flex: 0 0 24px; height: 1px; background: var(--accent-soft); }
.eyebrow::after { flex: 1; }

h1 {
  font-family: 'Fraunces', serif;
  font-weight: 400;
  font-size: clamp(2.5rem, 5vw, 3.75rem);
  line-height: 1.05;
  letter-spacing: -0.02em;
  margin-bottom: 16px;
}
h1 em { font-style: italic; font-weight: 300; color: var(--accent); }

.subtitle { color: var(--ink-dim); font-size: 15px; max-width: 640px; }

.section-label {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.18em;
  color: var(--ink-faint);
  margin-bottom: 16px;
  display: flex;
  align-items: center;
  gap: 12px;
}
.section-label .num { color: var(--accent); }
.section-label::after { content: ''; flex: 1; height: 1px; background: var(--line); }

.diagram-wrap {
  background: var(--bg-elev-1);
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 32px 24px 24px;
  margin-bottom: 32px;
  position: relative;
}
.diagram-wrap::before {
  content: '';
  position: absolute;
  top: 12px; left: 12px;
  width: 6px; height: 6px;
  border-radius: 50%;
  background: var(--accent);
  box-shadow: 0 0 8px var(--accent);
}

svg.diagram { width: 100%; height: auto; display: block; }

.node-rect {
  fill: var(--bg-elev-2);
  stroke: var(--line-strong);
  stroke-width: 1;
  transition: stroke 0.2s, fill 0.2s;
}
.node-rect.hpg { stroke: var(--hpg); }
.node-rect.hpa { stroke: var(--hpa); }
.node-rect.hpt { stroke: var(--hpt); }
.node-rect.prl { stroke: var(--prl); }
.node-rect.gh { stroke: var(--gh); }
.node-rect.metabolic { stroke: var(--metabolic); }
.node-rect.adrenergic { stroke: var(--adrenergic); }
.node-rect.lipid { stroke: var(--lipid); }
.node-rect.peripheral { stroke: var(--peripheral); }
.node-rect.tissue { stroke: var(--tissue); }
.node-rect.gut { stroke: var(--gut); }
.node-rect.heme { stroke: var(--heme); }
.node-rect.raas { stroke: var(--raas); }

.node-group { cursor: pointer; }
.node-group:hover .node-rect { fill: var(--bg-elev-3); }
.node-group.selected .node-rect {
  fill: var(--bg-elev-3);
  stroke: var(--accent);
  stroke-width: 2;
}

.node-label {
  font-family: 'Fraunces', serif;
  font-size: 13px;
  font-weight: 500;
  fill: var(--ink);
  text-anchor: middle;
  dominant-baseline: central;
  pointer-events: none;
}
.node-sub {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  fill: var(--ink-dim);
  text-anchor: middle;
  dominant-baseline: central;
  pointer-events: none;
}

.arr {
  stroke: var(--line-strong);
  stroke-width: 1;
  fill: none;
  transition: stroke 0.15s, stroke-width 0.15s, opacity 0.15s;
}
.arr.connected {
  stroke: var(--accent);
  stroke-width: 1.8;
  opacity: 1;
}
svg.diagram.has-hover .arr:not(.connected) { opacity: 0.18; }
svg.diagram.has-hover .arr-label { opacity: 0.4; transition: opacity 0.15s; }
.arr-label {
  font-family: 'JetBrains Mono', monospace;
  font-size: 9px;
  fill: var(--ink-faint);
  text-anchor: middle;
}

.section-divider {
  stroke: var(--line-strong);
  stroke-width: 1;
  stroke-dasharray: 4 5;
  opacity: 0.55;
}
.section-label-svg {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  text-transform: uppercase;
  letter-spacing: 0.22em;
  fill: var(--accent);
  text-anchor: middle;
}

.ind { opacity: 0; transition: opacity 0.25s; pointer-events: none; cursor: pointer; }
.ind.show { opacity: 1; pointer-events: auto; }
.ind-circle { stroke-width: 1.5; }
.ind-ring { fill: none; opacity: 0; }
.ind.mag-3 .ind-ring { opacity: 0.22; }
.ind.primary .ind-circle { fill: var(--primary); stroke: var(--primary-deep); }
.ind.benefit .ind-circle { fill: var(--benefit); stroke: var(--benefit-deep); }
.ind.adverse .ind-circle { fill: var(--adverse); stroke: var(--adverse-deep); }
.ind.incidental .ind-circle { fill: var(--incidental); stroke: var(--incidental-deep); }
.ind.mixed .ind-circle { fill: var(--mixed); stroke: var(--mixed-deep); }
.ind.primary .ind-ring { fill: var(--primary); }
.ind.benefit .ind-ring { fill: var(--benefit); }
.ind.adverse .ind-ring { fill: var(--adverse); }
.ind.incidental .ind-ring { fill: var(--incidental); }
.ind.mixed .ind-ring { fill: var(--mixed); }
.ind-text {
  font-family: 'JetBrains Mono', monospace;
  font-weight: 600;
  fill: var(--bg-deep);
  text-anchor: middle;
  dominant-baseline: central;
  pointer-events: none;
}

.legend {
  padding-top: 16px;
  margin-top: 20px;
  border-top: 1px solid var(--line);
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  color: var(--ink-dim);
  position: relative;
}
.legend-toggle {
  background: transparent;
  border: none;
  color: var(--ink-faint);
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.12em;
  padding: 4px 0;
  cursor: pointer;
  display: flex;
  align-items: center;
  gap: 8px;
  transition: color 0.15s;
}
.legend-toggle:hover { color: var(--accent); }
.legend-toggle-chevron {
  display: inline-block;
  font-size: 9px;
  transition: transform 0.2s;
}
.legend.collapsed .legend-toggle-chevron { transform: rotate(-90deg); }
.legend.collapsed .legend-content { display: none; }
.legend-content {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(220px, 1fr));
  gap: 14px 28px;
  margin-top: 14px;
}
.legend-item { display: flex; align-items: center; gap: 10px; }
.legend-dot {
  border-radius: 50%;
  flex-shrink: 0;
  display: inline-flex;
  align-items: center;
  justify-content: center;
  color: var(--bg-deep);
  font-weight: 600;
  font-size: 10px;
}
.legend-dot.size-1 { width: 10px; height: 10px; font-size: 7px; }
.legend-dot.size-2 { width: 14px; height: 14px; font-size: 10px; }
.legend-dot.size-3 { width: 18px; height: 18px; font-size: 12px; box-shadow: 0 0 0 4px rgba(201, 160, 76, 0.2); }
.legend-dot.primary { background: var(--primary); }
.legend-dot.benefit { background: var(--benefit); }
.legend-dot.adverse { background: var(--adverse); }
.legend-dot.incidental { background: var(--incidental); }
.legend-dot.mixed { background: var(--mixed); }
.legend-line { width: 24px; height: 2px; background: var(--line-strong); flex-shrink: 0; }
.legend-line.dashed { background: repeating-linear-gradient(to right, var(--line-strong) 0 4px, transparent 4px 7px); }
.legend-section-label {
  grid-column: 1 / -1;
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.18em;
  color: var(--ink-faint);
  margin-top: 4px;
  margin-bottom: -4px;
}
.legend-section-label:first-child { margin-top: 0; }

.drugs-section { margin-top: 40px; }

.controls-row {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 16px;
  padding: 12px 16px;
  background: var(--bg-elev-1);
  border: 1px solid var(--line);
  border-radius: 4px;
  margin-bottom: 16px;
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  color: var(--ink-dim);
  min-height: 44px;
}
.controls-row.has-active {
  border-color: var(--accent-deep);
  background: rgba(201, 160, 76, 0.06);
  color: var(--accent);
}
.controls-row-status .count { color: var(--accent); font-weight: 600; }
.clear-btn {
  background: transparent;
  border: 1px solid var(--line-strong);
  color: var(--ink-dim);
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.1em;
  padding: 6px 12px;
  border-radius: 3px;
  cursor: pointer;
  transition: all 0.15s;
}
.clear-btn:hover { border-color: var(--accent); color: var(--accent); }
.controls-row .hint { font-style: italic; color: var(--ink-faint); }

.controls-row-actions {
  display: flex;
  gap: 8px;
  align-items: center;
}

.drug-search-row {
  display: flex;
  align-items: center;
  gap: 16px;
  margin-bottom: 20px;
  position: sticky;
  top: 0;
  z-index: 5;
  background: var(--bg-deep);
  padding: 4px 0;
}
.drug-search-input {
  flex: 1;
  background: var(--bg-elev-2);
  border: 1px solid var(--line-strong);
  border-radius: 4px;
  color: var(--ink);
  font-family: 'Manrope', sans-serif;
  font-size: 13px;
  font-weight: 500;
  padding: 10px 14px 10px 38px;
  outline: none;
  transition: border-color 0.15s, background 0.15s, box-shadow 0.15s;
  box-shadow: inset 0 1px 2px rgba(0, 0, 0, 0.3);
  background-image: url("data:image/svg+xml;utf8,<svg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='none' stroke='%23A39B89' stroke-width='1.5' stroke-linecap='round'><circle cx='7' cy='7' r='5'/><line x1='10.6' y1='10.6' x2='14' y2='14'/></svg>");
  background-repeat: no-repeat;
  background-position: 12px center;
  background-size: 16px 16px;
}
.drug-search-input:focus {
  border-color: var(--accent);
  background-color: var(--bg-elev-3);
  box-shadow: inset 0 1px 2px rgba(0, 0, 0, 0.3), 0 0 0 2px rgba(201, 160, 76, 0.12);
}
.drug-search-input::placeholder {
  color: var(--ink-faint);
  font-weight: 400;
}
.drug-search-input::-webkit-search-cancel-button {
  -webkit-appearance: none;
  appearance: none;
  height: 12px;
  width: 12px;
  background-image: linear-gradient(45deg, transparent 45%, var(--ink-dim) 45%, var(--ink-dim) 55%, transparent 55%),
                    linear-gradient(-45deg, transparent 45%, var(--ink-dim) 45%, var(--ink-dim) 55%, transparent 55%);
  cursor: pointer;
}
.drug-search-meta {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--ink-faint);
  white-space: nowrap;
  min-width: 60px;
  text-align: right;
}

.drug-category { margin-bottom: 28px; }
.drug-category.no-matches { display: none; }

/* On wide screens, lay out drug categories in two independent vertical
   columns. Each column flows on its own so collapsing/expanding a category
   only shifts items below it within the same column — no row-height binding
   like a 2-col grid would have. Below 1100px, the columns stack naturally,
   preserving alphabetical order (col 1 holds A-mid, col 2 holds mid-Z). */
@media (min-width: 1100px) {
  #drug-categories {
    display: flex;
    gap: 32px;
    align-items: flex-start;
  }
  .drug-cats-col {
    flex: 1;
    min-width: 0;
  }
}

.drug-cat-name {
  font-family: 'Fraunces', serif;
  font-style: italic;
  font-weight: 400;
  font-size: 14px;
  color: var(--accent);
  margin-bottom: 10px;
  padding-left: 14px;
  border-left: 2px solid var(--accent-soft);
  cursor: pointer;
  user-select: none;
  display: flex;
  align-items: baseline;
  gap: 10px;
  transition: opacity 0.15s;
}
.drug-cat-name:hover { opacity: 0.85; }
.drug-cat-chevron {
  font-style: normal;
  font-size: 9px;
  color: var(--ink-faint);
  transition: transform 0.2s;
  display: inline-block;
}
.drug-category.collapsed .drug-cat-chevron { transform: rotate(-90deg); }
.drug-category.collapsed .drug-grid { display: none; }
.drug-cat-count {
  font-family: 'JetBrains Mono', monospace;
  font-style: normal;
  font-size: 10px;
  color: var(--ink-faint);
  font-weight: 400;
}
.drug-cat-count.has-active {
  color: var(--accent);
}
.drug-btn.hidden { display: none; }

/* Search-effect match borders — colored by how the drug affects the matched node.
   Active state (gold) wins via :not(.active) so a selected drug keeps its
   selected indicator regardless of how the current search categorizes it. */
.drug-btn.match-primary:not(.active) { border-color: var(--primary); box-shadow: inset 2px 0 0 var(--primary); }
.drug-btn.match-benefit:not(.active) { border-color: var(--benefit); box-shadow: inset 2px 0 0 var(--benefit); }
.drug-btn.match-adverse:not(.active) { border-color: var(--adverse); box-shadow: inset 2px 0 0 var(--adverse); }
.drug-btn.match-incidental:not(.active) { border-color: var(--incidental); box-shadow: inset 2px 0 0 var(--incidental); }

.drug-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(160px, 1fr));
  gap: 8px;
}

.drug-btn {
  background: var(--bg-elev-1);
  border: 1px solid var(--line);
  border-radius: 4px;
  color: var(--ink);
  font-family: 'Manrope', sans-serif;
  font-size: 13px;
  font-weight: 500;
  padding: 11px 14px;
  cursor: pointer;
  transition: all 0.15s;
  text-align: left;
  position: relative;
  line-height: 1.3;
}
.drug-btn:hover { border-color: var(--line-strong); background: var(--bg-elev-2); }
.drug-btn.active { background: var(--bg-elev-3); border-color: var(--accent); }
.drug-btn.active::before {
  content: '';
  position: absolute;
  left: -1px; top: -1px; bottom: -1px;
  width: 2px;
  background: var(--accent);
}
.drug-sub {
  display: block;
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--ink-faint);
  margin-top: 3px;
  font-weight: 400;
}
.drug-btn.active .drug-sub { color: var(--accent); }

/* Tier chips — shown inline within drug buttons that have multiple dose tiers.
   Inactive drugs show a passive "N doses" hint to advertise tier availability;
   active drugs show clickable tier chips with the current one highlighted. */
.tier-chips {
  display: flex;
  flex-wrap: wrap;
  gap: 4px;
  margin-top: 8px;
}
.tier-hint {
  font-family: 'JetBrains Mono', monospace;
  font-size: 9px;
  text-transform: uppercase;
  letter-spacing: 0.08em;
  color: var(--ink-faint);
  border: 1px dashed var(--line-strong);
  padding: 2px 6px;
  border-radius: 2px;
}
.drug-btn:hover .tier-hint { color: var(--ink-dim); border-color: var(--line-strong); }
.tier-chip {
  font-family: 'JetBrains Mono', monospace;
  font-size: 9px;
  text-transform: uppercase;
  letter-spacing: 0.08em;
  color: var(--ink-dim);
  background: var(--bg-elev-2);
  border: 1px solid var(--line-strong);
  padding: 2px 7px;
  border-radius: 2px;
  cursor: pointer;
  transition: all 0.12s;
}
.tier-chip:hover {
  color: var(--ink);
  border-color: var(--accent-soft);
}
.tier-chip.active {
  background: var(--accent);
  color: var(--bg-deep);
  border-color: var(--accent);
}

.tier-tag {
  display: inline-block;
  margin-left: 8px;
  font-family: 'JetBrains Mono', monospace;
  font-size: 9px;
  text-transform: uppercase;
  letter-spacing: 0.08em;
  color: var(--accent);
  background: rgba(201, 160, 76, 0.1);
  border: 1px solid var(--accent-deep);
  padding: 2px 6px;
  border-radius: 2px;
}

/* Phenotype section */
.phenotype-section {
  background: rgba(180, 160, 110, 0.04);
  border: 1px solid var(--line);
  border-left: 3px solid var(--peripheral);
  border-radius: 4px;
  padding: 14px 16px;
  margin-bottom: 24px;
}
.phenotype-section.collapsed { padding: 10px 14px 10px 16px; }
.phenotype-toggle {
  background: transparent;
  border: none;
  width: 100%;
  text-align: left;
  cursor: pointer;
  display: flex;
  align-items: center;
  gap: 10px;
  padding: 0;
  color: inherit;
  font: inherit;
}
.phenotype-chevron {
  display: inline-block;
  font-size: 10px;
  color: var(--ink-faint);
  transition: transform 0.2s;
  flex-shrink: 0;
}
.phenotype-section.collapsed .phenotype-chevron { transform: rotate(-90deg); }
.phenotype-toggle:hover .phenotype-chevron { color: var(--peripheral); }
.phenotype-section.collapsed .phenotype-content { display: none; }
.phenotype-content { margin-top: 12px; }
.phenotype-active-count {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--peripheral);
  background: rgba(184, 153, 104, 0.12);
  border: 1px solid var(--peripheral);
  padding: 1px 7px;
  border-radius: 2px;
  margin-left: auto;
  letter-spacing: 0.06em;
}
.phenotype-active-count:empty { display: none; }
.phenotype-title {
  font-family: 'Fraunces', serif;
  font-style: italic;
  font-size: 14px;
  color: var(--peripheral);
}
.phenotype-hint {
  font-family: 'Manrope', sans-serif;
  font-size: 11px;
  color: var(--ink-faint);
  margin-bottom: 12px;
  line-height: 1.4;
}
.phenotype-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(160px, 1fr));
  gap: 8px;
}
.phenotype-btn {
  background: var(--bg-elev-1);
  border: 1px dashed var(--peripheral);
  border-radius: 4px;
  color: var(--ink);
  font-family: 'Manrope', sans-serif;
  font-size: 13px;
  font-weight: 500;
  padding: 11px 14px;
  cursor: pointer;
  transition: all 0.15s;
  text-align: left;
  position: relative;
  line-height: 1.3;
}
.phenotype-btn:hover { border-color: var(--peripheral); border-style: solid; background: var(--bg-elev-2); }
.phenotype-btn.active {
  background: rgba(180, 160, 110, 0.12);
  border-color: var(--peripheral);
  border-style: solid;
}
.phenotype-btn.active::before {
  content: '';
  position: absolute;
  left: -1px; top: -1px; bottom: -1px;
  width: 2px;
  background: var(--peripheral);
}
.phenotype-sub {
  display: block;
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--ink-faint);
  margin-top: 3px;
  font-weight: 400;
}
.phenotype-btn.active .phenotype-sub { color: var(--peripheral); }
.phenotype-btn.disabled {
  opacity: 0.32;
  cursor: not-allowed;
  border-style: dashed;
}
.phenotype-btn.disabled:hover {
  border-color: var(--peripheral);
  background: var(--bg-elev-1);
}

/* Phenotype indicator in info panel */
.baseline-tag {
  display: inline-block;
  font-family: 'JetBrains Mono', monospace;
  font-size: 9px;
  text-transform: uppercase;
  letter-spacing: 0.08em;
  color: var(--peripheral);
  border: 1px solid var(--peripheral);
  padding: 2px 6px;
  border-radius: 2px;
  margin-right: 6px;
}
.chip.is-phenotype {
  border-style: dashed;
  border-color: var(--peripheral);
}

.info-panel {
  background: var(--bg-elev-1);
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 28px 32px;
  margin-top: 24px;
  min-height: 140px;
  position: relative;
}
.info-panel.empty { display: none; }
.info-panel::before {
  content: '';
  position: absolute;
  top: 0; left: 24px;
  width: 64px; height: 2px;
  background: var(--accent);
}
.info-class {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.18em;
  color: var(--accent);
  margin-bottom: 8px;
}
.info-name {
  font-family: 'Fraunces', serif;
  font-size: 24px;
  font-weight: 400;
  line-height: 1.15;
  margin-bottom: 14px;
  letter-spacing: -0.01em;
}
.info-desc { color: var(--ink-dim); font-size: 14px; line-height: 1.65; max-width: 70ch; }
.info-desc strong { color: var(--ink); font-weight: 500; }

.multi-drug-list { margin-top: 16px; }
.multi-drug-card {
  padding: 14px 0;
  border-top: 1px solid var(--line);
}
.multi-drug-card:first-child { border-top: none; padding-top: 0; }
.multi-drug-card-header {
  display: flex;
  align-items: baseline;
  gap: 12px;
  margin-bottom: 6px;
}
.multi-drug-name {
  font-family: 'Fraunces', serif;
  font-size: 17px;
  color: var(--ink);
}
.multi-drug-class {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--accent);
  text-transform: uppercase;
  letter-spacing: 0.12em;
}
.multi-drug-desc {
  color: var(--ink-dim);
  font-size: 13px;
  line-height: 1.6;
}

/* === Protocol presets (collapsible section, parallel to phenotype) === */
.protocols-section {
  background: rgba(201, 160, 76, 0.04);
  border: 1px solid var(--line);
  border-left: 3px solid var(--accent-soft);
  border-radius: 4px;
  padding: 14px 16px;
  margin-bottom: 18px;
}
.protocols-section.collapsed { padding: 10px 14px 10px 16px; }
.protocols-toggle {
  background: transparent;
  border: none;
  width: 100%;
  text-align: left;
  cursor: pointer;
  display: flex;
  align-items: center;
  gap: 10px;
  padding: 0;
  color: inherit;
  font: inherit;
}
.protocols-chevron {
  display: inline-block;
  font-size: 10px;
  color: var(--ink-faint);
  transition: transform 0.2s, color 0.15s;
  flex-shrink: 0;
}
.protocols-section.collapsed .protocols-chevron { transform: rotate(-90deg); }
.protocols-toggle:hover .protocols-chevron { color: var(--accent); }
.protocols-title {
  font-family: 'Fraunces', serif;
  font-style: italic;
  font-size: 14px;
  color: var(--accent);
}
.protocols-meta {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--ink-faint);
  margin-left: auto;
  letter-spacing: 0.04em;
}
.protocols-section.collapsed .protocols-content { display: none; }
.protocols-content { margin-top: 14px; }
.presets-section { margin-bottom: 22px; }
.presets-section:last-of-type { margin-bottom: 16px; }
.presets-section-header {
  display: flex;
  align-items: baseline;
  gap: 10px;
  margin-bottom: 10px;
}
.presets-eyebrow {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.18em;
  color: var(--accent);
}
.presets-list {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(280px, 1fr));
  gap: 8px;
}
.presets-empty {
  font-size: 12px;
  color: var(--ink-faint);
  font-style: italic;
  padding: 8px 2px;
}
.preset-item {
  position: relative;
  display: flex;
}
.preset-item .preset-load {
  flex: 1;
  text-align: left;
  background: var(--bg-elev-2);
  border: 1px solid var(--line);
  color: var(--ink);
  padding: 10px 12px;
  border-radius: 4px;
  cursor: pointer;
  font-family: inherit;
  transition: border-color 0.12s, background 0.12s;
}
.preset-item .preset-load:hover {
  border-color: var(--accent);
  background: var(--bg-elev-3);
}
.preset-item.user .preset-load { padding-right: 32px; }
.preset-item .preset-delete {
  position: absolute;
  right: 6px;
  top: 50%;
  transform: translateY(-50%);
  width: 22px;
  height: 22px;
  border: none;
  background: transparent;
  color: var(--ink-faint);
  cursor: pointer;
  font-size: 16px;
  line-height: 1;
  border-radius: 2px;
}
.preset-item .preset-delete:hover { color: var(--adverse); background: var(--bg-elev-3); }
.preset-name {
  display: block;
  font-family: 'Fraunces', serif;
  font-size: 14px;
  color: var(--ink);
  margin-bottom: 3px;
}
.preset-meta {
  display: block;
  font-family: 'JetBrains Mono', monospace;
  font-size: 9px;
  text-transform: uppercase;
  letter-spacing: 0.1em;
  color: var(--ink-faint);
}
.preset-desc {
  display: block;
  font-size: 11px;
  line-height: 1.5;
  color: var(--ink-dim);
}
.presets-save-row {
  display: flex;
  gap: 8px;
  padding-top: 14px;
  border-top: 1px solid var(--line);
}
.presets-save-input {
  flex: 1;
  padding: 8px 10px;
  background: var(--bg-elev-2);
  border: 1px solid var(--line);
  color: var(--ink);
  border-radius: 4px;
  font-family: inherit;
  font-size: 13px;
}
.presets-save-input:focus {
  outline: none;
  border-color: var(--accent);
}
#presets-save-btn:disabled {
  opacity: 0.45;
  cursor: not-allowed;
}

/* === Interactions panel === */
.interactions-list {
  margin-top: 20px;
  padding-top: 18px;
  border-top: 1px dashed var(--line-strong);
}
.interactions-header {
  display: flex;
  align-items: baseline;
  gap: 10px;
  margin-bottom: 12px;
}
.interactions-eyebrow {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.18em;
  color: var(--mixed);
}
.interactions-count {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--ink-faint);
  padding: 1px 6px;
  border: 1px solid var(--line-strong);
  border-radius: 8px;
}
.interaction-card {
  padding: 12px 14px;
  margin-bottom: 10px;
  background: var(--bg-elev-2);
  border-left: 2px solid var(--incidental);
  border-radius: 0 4px 4px 0;
}
.interaction-card.sev-caution     { border-left-color: var(--adverse); }
.interaction-card.sev-synergistic { border-left-color: var(--benefit); }
.interaction-card.sev-mechanistic { border-left-color: var(--accent); }
.interaction-card.sev-redundant   { border-left-color: var(--incidental); }

.interaction-card-header {
  display: flex;
  align-items: center;
  gap: 10px;
  margin-bottom: 4px;
}
.interaction-severity {
  font-family: 'JetBrains Mono', monospace;
  font-size: 9px;
  text-transform: uppercase;
  letter-spacing: 0.1em;
  padding: 2px 6px;
  border-radius: 2px;
  border: 1px solid currentColor;
}
.sev-caution     .interaction-severity { color: var(--adverse); }
.sev-synergistic .interaction-severity { color: var(--benefit); }
.sev-mechanistic .interaction-severity { color: var(--accent); }
.sev-redundant   .interaction-severity { color: var(--incidental); }

.interaction-label {
  font-family: 'Fraunces', serif;
  font-size: 15px;
  color: var(--ink);
}
.interaction-drugs {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--ink-faint);
  text-transform: uppercase;
  letter-spacing: 0.08em;
  margin-bottom: 8px;
}
.interaction-desc {
  font-size: 13px;
  line-height: 1.6;
  color: var(--ink-dim);
}

/* Marker on diagram indicators that have an interaction contributing.
   Stroke flips to mixed/purple regardless of effect type, plus a soft glow,
   so users can scan the diagram and spot interaction-affected nodes at once. */
.ind.has-ix .ind-circle {
  stroke: var(--mixed);
  stroke-dasharray: 3 2;
  stroke-width: 2.5px;
  filter: drop-shadow(0 0 3px rgba(184, 157, 198, 0.55));
}
/* Burst animation triggered by clicking the "N IX" badge in the sticky bar.
   Briefly scales and re-glows each interaction indicator so they pop. */
@keyframes ix-pulse {
  0%, 100% {
    filter: drop-shadow(0 0 3px rgba(184, 157, 198, 0.7));
    transform: scale(1);
  }
  50% {
    filter: drop-shadow(0 0 10px rgba(184, 157, 198, 1));
    transform: scale(1.45);
  }
}
.ind.has-ix.pulse .ind-circle {
  animation: ix-pulse 0.8s ease-in-out 3;
  transform-origin: center;
  transform-box: fill-box;
}
/* Click affordance on the IX badge in the sticky bar. */
.sticky-bar-summary .ix-badge { cursor: pointer; }
.sticky-bar-summary .ix-badge:hover { filter: brightness(1.15); }

/* Tooltip line styling for interaction-sourced contributors. */
.ind-tooltip-line.is-ix .ind-tooltip-drug { color: var(--mixed); }
.ind-tooltip-ix {
  font-family: 'JetBrains Mono', monospace;
  font-size: 8px;
  text-transform: uppercase;
  letter-spacing: 0.1em;
  padding: 1px 4px;
  margin-right: 5px;
  border: 1px solid var(--mixed);
  color: var(--mixed);
  border-radius: 2px;
  vertical-align: middle;
}

.node-info {
  display: none;
  background: var(--bg-elev-2);
  border-left: 2px solid var(--accent);
  padding: 16px 20px;
  margin-top: 16px;
  margin-bottom: 32px;
  font-size: 13px;
  color: var(--ink-dim);
}
.node-info.show { display: block; }
.node-info-name {
  font-family: 'Fraunces', serif;
  font-style: italic;
  color: var(--ink);
  font-size: 16px;
  margin-bottom: 6px;
}
.node-info-desc { margin-bottom: 14px; }

.node-pharm {
  padding-top: 12px;
  border-top: 1px solid var(--line);
}
.node-pharm-title {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.15em;
  color: var(--ink-faint);
  margin-bottom: 8px;
}
.node-pharm-row {
  display: flex;
  align-items: flex-start;
  gap: 10px;
  margin-bottom: 6px;
  flex-wrap: wrap;
}
.node-pharm-label {
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  color: var(--ink-dim);
  min-width: 80px;
  padding-top: 5px;
  flex-shrink: 0;
}
.node-pharm-label.raise { color: var(--benefit); }
.node-pharm-label.lower { color: var(--adverse); }
.node-pharm-chips {
  display: flex;
  flex-wrap: wrap;
  gap: 4px;
  flex: 1;
}
.drug-chip {
  display: inline-flex;
  align-items: center;
  gap: 5px;
  padding: 3px 9px;
  background: var(--bg-elev-3);
  border: 1px solid var(--line);
  border-radius: 3px;
  font-size: 11px;
  font-family: 'JetBrains Mono', monospace;
  color: var(--ink-dim);
  cursor: pointer;
  transition: all 0.12s;
  user-select: none;
}
.drug-chip:hover {
  background: var(--bg-elev-1);
  color: var(--ink);
  border-color: var(--line-strong);
}
.drug-chip.active {
  background: var(--accent);
  color: var(--bg-deep);
  border-color: var(--accent);
}
.drug-chip .chip-meta {
  font-size: 9px;
  opacity: 0.65;
  text-transform: uppercase;
  letter-spacing: 0.04em;
}
.chips-empty {
  color: var(--ink-faint);
  font-style: italic;
  font-size: 11px;
  padding-top: 5px;
}

footer {
  margin-top: 48px;
  padding-top: 24px;
  border-top: 1px solid var(--line);
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  color: var(--ink-faint);
  display: flex;
  justify-content: space-between;
  flex-wrap: wrap;
  gap: 12px;
}

@media (max-width: 720px) {
  body { padding: 16px 14px 48px; }
  header { padding-bottom: 18px; margin-bottom: 22px; }
  h1 { font-size: clamp(1.75rem, 6vw, 2.5rem); margin-bottom: 12px; }
  .eyebrow { margin-bottom: 10px; font-size: 10px; }
  .subtitle { font-size: 13px; }
  .diagram-wrap {
    padding: 16px 12px;
    overflow-x: auto;
    -webkit-overflow-scrolling: touch;
    /* Gradient fade on right edge hints that the diagram scrolls horizontally.
       Pinned to the wrap (not the SVG) so it doesn't slide with scroll. */
    background-image:
      radial-gradient(ellipse at top, rgba(201, 160, 76, 0.04), transparent 60%),
      linear-gradient(to right, transparent calc(100% - 28px), rgba(15, 18, 18, 0.85) 100%);
  }
  svg.diagram { min-width: 640px; }
  .sticky-bar-inner { padding: 6px 12px; gap: 8px; min-height: 40px; }
  .sticky-bar-nav { gap: 1px; }
  .sticky-bar-nav a { padding: 4px 7px; font-size: 9px; letter-spacing: 0.06em; }
  .sticky-bar-clear { padding: 4px 8px; font-size: 9px; }
  .info-panel { padding: 20px; }
  .info-name { font-size: 20px; }
  .drug-grid { grid-template-columns: 1fr 1fr; }
  .node-pharm-label { min-width: auto; padding-top: 2px; }

  .tier-chip {
    font-size: 11px;
    padding: 6px 10px;
    min-height: 28px;
  }
  .sex-btn,
  .baseline-edit-btn,
  .baseline-reset-btn {
    font-size: 11px;
    padding: 8px 14px;
    min-height: 36px;
  }
  .drug-search-input {
    font-size: 16px;
    padding: 12px 14px;
    min-height: 44px;
  }
  .drug-cat-name {
    padding-top: 10px;
    padding-bottom: 10px;
    min-height: 44px;
  }
  .drug-btn,
  .phenotype-btn {
    padding: 12px 14px;
    min-height: 48px;
  }
  .lab-row { padding: 10px 8px; }
}

@media (max-width: 480px) {
  body { padding: 14px 12px 32px; }
  .drug-grid { grid-template-columns: 1fr; }
  .phenotype-grid { grid-template-columns: 1fr; }
  .lab-grid { grid-template-columns: 1fr; }
  .legend-content { grid-template-columns: 1fr; }
  .info-panel { padding: 16px; }
  .lab-panel { padding: 16px; }
  .drug-category { margin-bottom: 20px; }
  .controls-row {
    flex-direction: column;
    align-items: stretch;
    gap: 10px;
  }
  .controls-row-actions { justify-content: flex-end; }
  .sticky-bar-nav a { padding: 4px 6px; font-size: 9px; letter-spacing: 0.04em; }
  .sticky-bar-inner { gap: 6px; }
  .sticky-bar-chip { font-size: 9px; padding: 3px 7px; }
}

/* LAB PANEL */
.lab-panel {
  background: var(--bg-elev-1);
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 28px 32px;
  margin-bottom: 32px;
  position: relative;
}
/* Decorative status dot — only visible when the panel is expanded, since on
   the collapsed single-line header it crashes into the chevron+title. */
.lab-panel:not(.collapsed)::before {
  content: '';
  position: absolute;
  top: 12px; left: 12px;
  width: 6px; height: 6px;
  border-radius: 50%;
  background: var(--benefit);
  box-shadow: 0 0 8px var(--benefit);
}
.lab-panel-header {
  display: flex;
  justify-content: space-between;
  align-items: flex-start;
  gap: 24px;
  margin-bottom: 20px;
  padding-bottom: 16px;
  border-bottom: 1px solid var(--line);
}
@media (max-width: 960px) {
  .lab-panel-header { flex-direction: column; gap: 12px; }
}
.lab-panel-hint {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--ink-faint);
  font-style: italic;
  flex: 1;
  min-width: 0;
}
.lab-panel-hint.active { color: var(--ink-dim); }

.sex-selector {
  display: flex;
  flex-wrap: wrap;
  gap: 4px;
  flex-shrink: 0;
}
.sex-btn {
  appearance: none;
  background: transparent;
  border: 1px solid var(--line-strong);
  color: var(--ink-dim);
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.06em;
  padding: 5px 10px;
  border-radius: 999px;
  cursor: pointer;
  transition: color 0.15s, border-color 0.15s, background 0.15s;
}
.sex-btn:hover { color: var(--ink); border-color: var(--accent-soft); }
.sex-btn.active {
  background: rgba(201, 160, 76, 0.12);
  border-color: var(--accent);
  color: var(--accent);
}
.lab-range.sex-aware { color: var(--accent); }

/* Baseline edit mode — "Self" phenotype editing */
.lab-panel-actions {
  display: flex;
  gap: 6px;
  flex-shrink: 0;
  align-items: center;
  flex-wrap: wrap;
}

/* Chevron-header toggle (matches phenotype / legend pattern). When collapsed,
   only the toggle is visible. Lab grid + controls live inside .lab-panel-content. */
.lab-panel-toggle {
  background: transparent;
  border: none;
  width: 100%;
  text-align: left;
  cursor: pointer;
  display: flex;
  align-items: center;
  gap: 12px;
  padding: 0;
  color: inherit;
  font: inherit;
}
.lab-panel-chevron {
  display: inline-block;
  font-size: 11px;
  color: var(--ink-faint);
  transition: transform 0.2s, color 0.15s;
  flex-shrink: 0;
}
.lab-panel.collapsed .lab-panel-chevron { transform: rotate(-90deg); }
.lab-panel-toggle:hover .lab-panel-chevron { color: var(--accent); }
.lab-panel-title {
  font-family: 'Fraunces', serif;
  font-style: italic;
  font-size: 16px;
  color: var(--accent);
}
.lab-panel-active-count {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--accent);
  background: rgba(201, 160, 76, 0.1);
  border: 1px solid var(--accent-deep);
  padding: 1px 7px;
  border-radius: 2px;
  margin-left: auto;
  letter-spacing: 0.06em;
}
.lab-panel-active-count:empty { display: none; }
.lab-panel.collapsed .lab-panel-content { display: none; }
.lab-panel.collapsed {
  padding-top: 18px;
  padding-bottom: 18px;
}
.lab-panel-content { margin-top: 18px; }
.baseline-edit-btn, .baseline-reset-btn {
  appearance: none;
  background: transparent;
  border: 1px dashed var(--peripheral);
  color: var(--peripheral);
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.08em;
  padding: 5px 11px;
  border-radius: 3px;
  cursor: pointer;
  transition: all 0.15s;
}
.baseline-edit-btn:hover, .baseline-reset-btn:hover {
  border-style: solid;
  background: rgba(184, 153, 104, 0.08);
}
.baseline-edit-btn.active {
  border-style: solid;
  background: rgba(184, 153, 104, 0.14);
  color: var(--accent);
  border-color: var(--accent);
}
.baseline-reset-btn {
  border-color: var(--line-strong);
  color: var(--ink-dim);
}
.baseline-reset-btn:hover {
  border-color: var(--adverse);
  color: var(--adverse);
}

/* While editing: invite drag interaction on lab bars, kill marker animation
   so it tracks the cursor in real time, and show snap-point ticks. */
body.editing-baseline .lab-panel {
  box-shadow: 0 0 0 1px var(--peripheral), 0 0 24px -8px rgba(184, 153, 104, 0.4);
}
body.editing-baseline .lab-bar {
  cursor: ew-resize;
  background: var(--bg-elev-3);
  /* 7 snap ticks at 11%, 24%, 37%, 50%, 63%, 76%, 89% — matches the magnitude grid */
  background-image:
    linear-gradient(to right, transparent 0, transparent calc(11% - 1px), rgba(184, 153, 104, 0.4) calc(11% - 1px), rgba(184, 153, 104, 0.4) calc(11% + 1px), transparent calc(11% + 1px)),
    linear-gradient(to right, transparent 0, transparent calc(24% - 1px), rgba(184, 153, 104, 0.3) calc(24% - 1px), rgba(184, 153, 104, 0.3) calc(24% + 1px), transparent calc(24% + 1px)),
    linear-gradient(to right, transparent 0, transparent calc(37% - 1px), rgba(184, 153, 104, 0.25) calc(37% - 1px), rgba(184, 153, 104, 0.25) calc(37% + 1px), transparent calc(37% + 1px)),
    linear-gradient(to right, transparent 0, transparent calc(63% - 1px), rgba(184, 153, 104, 0.25) calc(63% - 1px), rgba(184, 153, 104, 0.25) calc(63% + 1px), transparent calc(63% + 1px)),
    linear-gradient(to right, transparent 0, transparent calc(76% - 1px), rgba(184, 153, 104, 0.3) calc(76% - 1px), rgba(184, 153, 104, 0.3) calc(76% + 1px), transparent calc(76% + 1px)),
    linear-gradient(to right, transparent 0, transparent calc(89% - 1px), rgba(184, 153, 104, 0.4) calc(89% - 1px), rgba(184, 153, 104, 0.4) calc(89% + 1px), transparent calc(89% + 1px));
  background-repeat: no-repeat;
}
body.editing-baseline .lab-bar-marker {
  transition: none;
  background: var(--peripheral);
  box-shadow: 0 0 8px rgba(184, 153, 104, 0.5);
  width: 4px;
  height: 18px;
  top: -5px;
  cursor: grab;
}
body.editing-baseline .lab-bar-marker:active { cursor: grabbing; }
body.editing-baseline .lab-row { cursor: default; }
body.editing-baseline .lab-row:hover { background: transparent; }
body.editing-baseline .lab-flag { color: var(--peripheral); }

.lab-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(260px, 1fr));
  gap: 32px;
}
@media (max-width: 720px) {
  .lab-grid { gap: 24px; }
  .lab-panel { padding: 20px; }
}

.lab-section-title {
  font-family: 'Fraunces', serif;
  font-style: italic;
  font-weight: 400;
  font-size: 14px;
  color: var(--accent);
  padding-left: 12px;
  border-left: 2px solid var(--accent-soft);
  margin-bottom: 18px;
}

.lab-rows { display: flex; flex-direction: column; gap: 18px; }

.lab-row {
  cursor: pointer;
  transition: background 0.15s;
  padding: 6px 8px;
  border-radius: 4px;
  margin: 0 -8px;
}
.lab-row:hover { background: var(--bg-elev-2); }

.lab-row-top {
  display: flex;
  justify-content: space-between;
  align-items: baseline;
  margin-bottom: 8px;
  gap: 12px;
}
.lab-name {
  font-family: 'Manrope', sans-serif;
  font-size: 13px;
  font-weight: 500;
  color: var(--ink);
}
.lab-flag {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  font-weight: 600;
  letter-spacing: 0.1em;
  color: var(--ink-faint);
  white-space: nowrap;
}
.lab-flag.flag-high, .lab-flag.flag-low {
  color: var(--adverse);
}
.lab-flag.flag-shift-up, .lab-flag.flag-shift-down {
  color: var(--accent);
}

.lab-bar {
  height: 8px;
  background: var(--bg-elev-3);
  border-radius: 4px;
  position: relative;
  overflow: visible;
  margin-bottom: 6px;
}
.lab-bar::before {
  content: '';
  position: absolute;
  left: 20%;
  width: 60%;
  top: 0;
  bottom: 0;
  background: rgba(79, 184, 146, 0.15);
  border-left: 1px dashed rgba(79, 184, 146, 0.45);
  border-right: 1px dashed rgba(79, 184, 146, 0.45);
}
.lab-bar-marker {
  position: absolute;
  top: -3px;
  width: 3px;
  height: 14px;
  background: var(--ink-dim);
  border-radius: 1.5px;
  transform: translateX(-50%);
  transition: left 0.4s cubic-bezier(0.4, 0, 0.2, 1), background 0.2s, box-shadow 0.2s;
  left: 50%;
  z-index: 2;
}
.lab-bar-marker.flag-high, .lab-bar-marker.flag-low {
  background: var(--adverse);
  box-shadow: 0 0 8px rgba(224, 117, 80, 0.5);
}
.lab-bar-marker.flag-shift-up, .lab-bar-marker.flag-shift-down {
  background: var(--accent);
}

.lab-range {
  font-family: 'JetBrains Mono', monospace;
  font-size: 10px;
  color: var(--ink-faint);
}

.tooltip {
  position: fixed;
  background: var(--bg-elev-3);
  border: 1px solid var(--line-strong);
  border-radius: 4px;
  padding: 10px 14px;
  font-size: 12px;
  color: var(--ink);
  max-width: min(320px, calc(100vw - 24px));
  pointer-events: none;
  opacity: 0;
  transition: opacity 0.15s;
  z-index: 100;
  line-height: 1.5;
  box-shadow: 0 4px 12px rgba(0,0,0,0.4);
}
.tooltip.show { opacity: 1; }
.tooltip-name {
  font-family: 'Fraunces', serif;
  font-style: italic;
  color: var(--accent);
  margin-bottom: 4px;
  font-size: 13px;
}

.ind-tooltip-line {
  display: flex;
  align-items: center;
  gap: 8px;
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  padding: 2px 0;
}
.ind-tooltip-arrow {
  font-weight: 600;
  width: 12px;
  text-align: center;
}
.ind-tooltip-arrow.up { color: var(--benefit); }
.ind-tooltip-arrow.down { color: var(--adverse); }
.ind-tooltip-drug { color: var(--ink); flex: 1; }
.ind-tooltip-meta {
  color: var(--ink-faint);
  font-size: 10px;
  text-transform: uppercase;
}
.ind-tooltip-net {
  margin-top: 8px;
  padding-top: 6px;
  border-top: 1px solid var(--line);
  font-family: 'JetBrains Mono', monospace;
  font-size: 11px;
  color: var(--ink-dim);
}